- Sektör: Government; Health care
- Number of terms: 6957
- Number of blossaries: 0
- Company Profile:
The National Cancer Institute (NCI) is part of the National Institutes of Health (NIH), which is one of 11 agencies that compose the Department of Health and Human Services (HHS). The NCI, established under the National Cancer Institute Act of 1937, is the Federal Government's principal agency for ...
An injectable collagen matrix gel containing the antimetabolite methotrexate and the sympathicomimetic agent epinephrine with potential antineoplastic activity. After intratumoral injection, methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Epinephrine, a potent vasoconstrictor, is added to the gel to enhance penetration of methotrexate into the tumor tissue and reduce dispersion to the surrounding tissues thereby enhancing the local concentration of methotrexate and increasing its anti-tumor activity. Intratumoral injection of methotrexate combined with epinephrine may potentially increase chemotherapeutic efficacy compared to systemic administration and reduce systemic toxicity and side effects.
Industry:Pharmaceutical
An injectable emulsion formulation containing the taxane docetaxel, a semisynthetic analogue of paclitaxel, with antineoplastic activity. Docetaxel binds specifically to the beta-tubulin subunit of the microtubule, stabilizing tubulin and inhibiting microtubule disassembly, which results in cell-cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and induces various mediators of the inflammatory response. Docetaxel emulsion ANX-514 is formulated without polysorbate 80 or other detergents in order to reduce the incidence and severity of hypersensitivity reactions. In addition, the exclusion of polysorbate 80 in this formulation precludes foaming during the preparation process, thus facilitating preparation and administration.
Industry:Pharmaceutical
An injectable formulation containing the taxane docetaxel, a semisynthetic analogue of paclitaxel, with antineoplastic activity. Docetaxel binds specifically to the beta-tubulin subunit of the microtubule, stabilizing tubulin and inhibiting microtubule disassembly, which results in cell-cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and induces various mediators of the inflammatory response.
Industry:Pharmaceutical
An injectable formulation of the radioisotope yttrium Y 90 encapsulated in resin microspheres with potential antineoplastic activity. When injected into arterial vasculature supplying the tumor, yttrium Y 90 resin microspheres occlude tumor blood vessels and selectively deliver a cytotoxic dose of beta emitting yttrium Y 90 to the tumor site, which may result in tumor cell death and tumor regression.
Industry:Pharmaceutical
An injectable microemulsion of a purified oil extracted from the seeds of the traditional Chinese medicinal herb Coix lacryma-jobi (Job's tears), with potential antineoplastic activity. Although the exact mechanism of action is unknown, kanglaite exhibits an antineoplastic effect, potentially via interfering with the cell cycle and halting tumor cells in the G2/M phase, which may eventually inhibit mitosis and proliferation of cancer cells.
Industry:Pharmaceutical
An injectable radiopharmaceutical formulation containing human serum albumin (HSA) labeled with technetium-99m (Tc99m) in macroaggregates (MAA) with diagnostic imaging activity. Technetium Tc 99m-labeled macroaggregated albumin contains the gamma-emitting Tc99m, a metastable nuclide of molybdenum-99. Upon injection into the hepatic artery and upon SPECT (single photon emission computed tomography) imaging, distribution patterns and possible prediction of expected distribution of agents with similar particle sizes within the liver can be assessed and may give a prediction about the tumor response upon administration of such agents.
Industry:Pharmaceutical
An injectable radiopharmaceutical formulation containing human serum albumin (HSA) microspheres labeled with technetium-99m (Tc-99m) with diagnostic imaging activity. Technetium Tc 99m-labeled albumin microspheres contain the gamma-emitting Tc99m, a metastable nuclide of molybdenum-99. Upon injection into the hepatic artery, the radionuclide portion allows for SPECT (single photon emission computed tomography) imaging of distribution patterns of the albumin microspheres. This may possibly predict the distribution of other agents with similar particle sizes within the liver and may give a prediction of the tumor response upon administration of such agents.
Industry:Pharmaceutical
An injectable ultrasound contrast media formulation composed of microbubbles of stabilized sulphur hexafluoride (SF6) in sodium chloride solution. With stabilized sulphur hexafluoride microbubble-based contrast agent, ultrasound waves are scattered and reflected at the microbubble-blood interface during ultrasound imaging, thereby enhancing blood vessel visualization and the contrast between blood vessels and adjacent tissues.
Industry:Pharmaceutical
An inorganic chemical with antiseptic activity. Silver nitrate can potentially be used as a cauterizing or sclerosing agent.
Industry:Pharmaceutical
An inorganic form of the trace element selenium with potential antineoplastic activity. Selenium, administered in the form of sodium selenite, is reduced to hydrogen selenide (H2Se) in the presence of glutathione (GSH) and subsequently generates superoxide radicals upon reaction with oxygen. This may inhibit the expression and activity of the transcription factor Sp1; in turn Sp1 down-regulates androgen receptor (AR) expression and blocks AR signaling. Eventually, selenium may induce apoptosis in prostate cancer cells and inhibit tumor cell proliferation.
Industry:Pharmaceutical
